Chlorpropamide

Chlorpropamide

CAT N°: 26087
Price:

From 102.00 86.70

Chlorpropamide is a first generation sulfonylurea.{48076} It increases glycolysis by increasing fructose-2,6-bisphosphate levels and inhibits glucagon-induced gluconeogenesis by augmenting the effect of insulin in isolated rat hepatocytes when used at a concentration of 0.2 mM. Chlorpropamide reverses increases in blood glucose levels induced by hydrochlorothiazide (Item No. 21304) and previous insulin in a rabbit model of diabetes when administered in a single 250 mg/kg dose or repeated doses of 10 mg/kg per day for six days.{48077} Formulations containing chlorpropamide have been used as adjuncts to diet and exercise in the treatment of type 2 diabetes.

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