Imperatorin

Imperatorin

CAT N°: 26070
Price:

From 111.00 94.35

Imperatorin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities, including anticancer, anti-inflammatory, and antioxidant properties.{47081,47082,47083} It decreases MCL-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in doxorubicin-resistant HepG2 (R-HepG2) cells, an effect that can be reversed by overexpression of MCL-1.{47081} Imperatorin inhibits the growth of doxorubicin-resistant and -sensitive HepG2 cells in vitro (IC50s = 28.1 and 43.3 ?M, respectively) and reduces tumor growth in an R-HepG2 mouse xenograft model when administered at a dose of 50 mg/kg. Imperatorin inhibits LPS-induced increases in p38 MAPK, JNK, and I?B? phosphorylation, TNF-?, IL-6, and IL-1? protein levels, and nuclear localization of NF-?B p65 in RAW 264.7 macrophages.{47082} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS radicals (EC50s = 19.48 and 10.93 ?M, respectively).{47083} Imperatorin also has antibacterial, antiviral, and anticonvulsant activities.{47081,47082}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one
  • Correlated keywords
    • 70102-00-0 Angelica anti-cancer oxidant MCL1 Hep G2 RHepG2 p 38 I? B? TNF? IL6 IL1? NF?B 65 bacterial antiinflammatory RAW264.7 viral convulsant isopentenyloxypsoralene NSC402949 ammidin marmelide
  • Product Overview:
    Imperatorin is a furanocoumarin that has been found in A. dahurica and has diverse biological activities, including anticancer, anti-inflammatory, and antioxidant properties.{47081,47082,47083} It decreases MCL-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in doxorubicin-resistant HepG2 (R-HepG2) cells, an effect that can be reversed by overexpression of MCL-1.{47081} Imperatorin inhibits the growth of doxorubicin-resistant and -sensitive HepG2 cells in vitro (IC50s = 28.1 and 43.3 ?M, respectively) and reduces tumor growth in an R-HepG2 mouse xenograft model when administered at a dose of 50 mg/kg. Imperatorin inhibits LPS-induced increases in p38 MAPK, JNK, and I?B? phosphorylation, TNF-?, IL-6, and IL-1? protein levels, and nuclear localization of NF-?B p65 in RAW 264.7 macrophages.{47082} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS radicals (EC50s = 19.48 and 10.93 ?M, respectively).{47083} Imperatorin also has antibacterial, antiviral, and anticonvulsant activities.{47081,47082}

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