Territorial Availability: Available through Bertin Technologies only in France
- Synonyms
- 3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-methyl-N-nitro-4H-1,3,5-oxadiazin-4-imine
- Correlated keywords
- Aphis Myzus Nilaparvata Brown planthopper Spodoptera Egyptian cotton leafworm Diabrotica cucumber beetle Heliothis Noctuidae Actara 25WG 25 500-WG 2GR 500WG Adage 5FS 5-FS CGA 293343 CGA293343 Centric Cruiser 350FS 350 600FS A 9765 A9765 Diacloden FS350 FS600 Flagship Meridian Optigard Platinum 240SC 240-SC Thiamethoxam WS 70 Xamox Syngenta
- Product Overview:
Thiamethoxam is a neonicotinoid insecticide and a precursor to the neonicotinoid insecticide clothianidin.{45016,45017} It binds to nicotinic acetylcholine receptors with low affinity (nAChRs; IC50 = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = >3,000 nM).{45017} Thiamethoxam induces mortality in a variety of insects, including A. craccivora, M. persicae, N. lugens, and S. littoralis when administered in contact/feeding assays (LC80s = 12, 3, 0.8, and 3 mg AI/L, respectively) and via systemic administration (LC80s = 0.8, 0.2, 0.05, and 0.8 mg AI/L, respectively) as well as D. balteata in a contact/feeding assay (LC50 = 0.8 mg AI/L).{45016} Thiamethoxam also induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays when used at a concentration of 200 mg/L.{45017} Formulations containing thiamethoxam have been used in the control of insects in agriculture.
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.