Pravastatin-d<sub>3</sub> (sodium salt)

Pravastatin-d3 (sodium salt)

CAT N°: 25464
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From 182.00 154.70

Pravastatin-d3 is intended for use as an internal standard for the quantification of pravastatin (Item Nos. 10010342 | 10010343) by GC- or LC-MS. Pravastatin is a potent and competitive HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule) that is a ring-hydroxylated metabolite of mevastatin (Item No. 10010340).{15312} In vivo, pravastatin reduces total plasma cholesterol levels by 29% in dogs when administered at a dose of 20 mg/kg per day for five weeks. Formulations containing pravastatin have been used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.

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