Senkyunolide A

Senkyunolide A

CAT N°: 25199
Price:

From 54.00 45.90

Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities.{42461} It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml.{42462} It also reverses increases in protein levels of phosphatase 2A (PP2A) and ?-synuclein and reverses decreases in the phosphorylated forms of PP2A and ?-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 µM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 µM).{42463}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3S)-3-butyl-4,5-dihydro-1(3H)-isobenzofuranone
  • Correlated keywords
    • 62006-39-7 cyto-protective anti-proliferative PC-12 PP-2A PP2-A HT29 CCD18Co CCD18-Co noncancerous
  • Product Overview:
    Senkyunolide A is a phthalide originally isolated from celery seed essential oil that has cytoprotective and antiproliferative activities.{42461} It protects against cell injury induced by corticosterone in PC12 cells in a time-dependent manner when used at concentrations ranging from 0.125 to 0.5 mg/ml and reduces corticosterone-induced apoptosis at a concentration of 0.5 mg/ml.{42462} It also reverses increases in protein levels of phosphatase 2A (PP2A) and ?-synuclein and reverses decreases in the phosphorylated forms of PP2A and ?-synuclein. Senkyunolide A inhibits cell proliferation of HT-29 colon cancer (IC50 = 54.17 µM) but not non-cancerous human CCD-18Co colon cells (IC50 = 109.11 µM).{42463}

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