Soyasaponin Bb

Soyasaponin Bb

CAT N°: 25140
Price:

From 48.00 40.80

Soyasaponin Bb is a triterpenoid saponin that has been found in soy and has enzyme inhibitory, antimetastatic, anti-inflammatory, and neuroprotective biological activities.{43236,43237,43238,43239,43240,43241} It selectively inhibits human recombinant and porcine kidney renin (IC50s = 30 and 30 ?g/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit angiotensin converting enzyme (ACE) when used at a concentration of 100 ?g/ml.{43237} Soyasaponin Bb inhibits the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 ?M) and decreases levels of ?2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro when used at a concentration of 75 ?M.{43238,43239} It also dose-dependently increases viability and mRNA expression of heme oxygenase-1 (HO-1) in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress.{43240} Soyasaponin Bb (10 mg/kg per day) increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in a rat model of learning and memory impairment induced by ibotenic acid (Item No. 14584).{43241}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3?,4?,22?)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-?-L-mannopyranosyl-(1?2)-O-?-D-galactopyranosyl-(1?2)-?-D-glucopyranosiduronic acid
  • Correlated keywords
    • 55366-25-1 189220-80-2 220640-76-6 868560-68-3 B-16 F-10 antiinflammatory anti-metastic HO1 BRL3A SCM 3B SCM3B neuro-protective ST3-GAL1 ST-3 GAL-1 Soysaponin
  • Product Overview:
    Soyasaponin Bb is a triterpenoid saponin that has been found in soy and has enzyme inhibitory, antimetastatic, anti-inflammatory, and neuroprotective biological activities.{43236,43237,43238,43239,43240,43241} It selectively inhibits human recombinant and porcine kidney renin (IC50s = 30 and 30 ?g/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit angiotensin converting enzyme (ACE) when used at a concentration of 100 ?g/ml.{43237} Soyasaponin Bb inhibits the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 ?M) and decreases levels of ?2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro when used at a concentration of 75 ?M.{43238,43239} It also dose-dependently increases viability and mRNA expression of heme oxygenase-1 (HO-1) in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress.{43240} Soyasaponin Bb (10 mg/kg per day) increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in a rat model of learning and memory impairment induced by ibotenic acid (Item No. 14584).{43241}

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