Magnoflorine

Magnoflorine

CAT N°: 25122
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146.00 124.10

Magnoflorine is an alkaloid and a major constituent of S. acutum that has diverse biological activities.{48045,48046,48047,48048} It reduces hemolysis induced by lysophosphatidylcholine (LPC), but not NaCl, in a rat erythrocyte suspension when used at concentrations ranging from 0.01 to 10 ?M.{48045} Magnoflorine (10 ?M) induces intracellular chloride influx in neuroblastoma cells, an effect that is reversed by the GABAA receptor antagonist bicuculline (Item No. 11727).{48046} It reduces TNF-?-induced NF-?B expression as well as production of IL-6 and IL-8 in BEAS-2B cells.{48047} In vivo, magnoflorine (20 mg/kg, i.p.) improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment.{48048}

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