Atractylenolide I

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 4aS,5,6,7,8,8aS-hexahydro-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan-2(4H)-one
• Correlated keywords
  • Atractylodes antiinflammatory antiangiogenic antitumor depressant TNF? IL1? IL6 T24 RT-4 253-J 5HT Hydroxytryptamine Arterenol Levarterenol NE L-Noradrenaline ATL1 AOI ATR-1 AT-I ATR1 ATI AO-I ATL-1
• Product Overview:
  Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties.{39945,39946,39947,39948} It inhibits LPS-induced increases in TNF-? and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 ?M, respectively).{39945} Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund’s complete adjuvant (FCA).{39946} It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-?, IL-1?, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 ?M) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner.{39947} In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; Item No. 14332) and norepinephrine (Item No. 16673) and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.{39948}