4-Methylumbelliferyl 2-sulfamino-2-deoxy-?-D-Glucopyranoside (sodium salt)

4-Methylumbelliferyl 2-sulfamino-2-deoxy-?-D-Glucopyranoside (sodium salt)

CAT N°: 24931
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From 105.00 89.25

4-Methylumbelliferyl 2-sulfamino-2-deoxy-?-D-Glucopyranoside (4-MU-?-GlcNS) is a fluorogenic substrate of heparin sulphamidase.{39610} Heparin sulphamidase cleaves 4-MU-?-GlcNS to yield 4-MU-?-GlcNH2, which is then cleaved by ?-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm.{39610,27251} The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251} 4-MU-?-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.{39611}

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