Amylin (human) (amidated) (trifluoro<wbr/>acetate salt)

Amylin (human) (amidated) (trifluoroacetate salt)

CAT N°: 24895
Price:

From 342.00 290.70

Amylin is a peptide hormone secreted from pancreatic ?-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.{35231} Native amylin is a cleavage product of proamylin that is processed and amidated at the C-terminus, a modification that is required for its biological activities.{41794} Amidated amylin increases the rate of glycogen synthesis induced by insulin in isolated rat soleus muscle when used at a concentration of 1 nM, while linear non-amidated amylin has no effect. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes and, in vitro, amidated amylin is more amyloidogenic than the free acid form.{35232,41795} Amylin (human) (amidated) is a 37-residue amidated form of amylin that contains a disulfide bridge between cysteines two and seven.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • cyclic (2?7)-disulfide, L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-L-tyrosinamide, trifluoroacetate salt
  • Correlated keywords
    • 122384-88-7 126698-61-1 AC001 AC 001 amlintide
  • Product Overview:
    Amylin is a peptide hormone secreted from pancreatic ?-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.{35231} Native amylin is a cleavage product of proamylin that is processed and amidated at the C-terminus, a modification that is required for its biological activities.{41794} Amidated amylin increases the rate of glycogen synthesis induced by insulin in isolated rat soleus muscle when used at a concentration of 1 nM, while linear non-amidated amylin has no effect. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes and, in vitro, amidated amylin is more amyloidogenic than the free acid form.{35232,41795} Amylin (human) (amidated) is a 37-residue amidated form of amylin that contains a disulfide bridge between cysteines two and seven.

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