Urocortin (human) (trifluoroacetate salt)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • L-?-aspartyl-L-asparaginyl-L-prolyl-L-seryl-L-leucyl-L-seryl-L-isoleucyl-L-?-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-threonyl-L-leucyl-L-leucyl-L-?-glutamyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-glutaminyl-L-seryl-L-glutaminyl-L-arginyl-L-?-glutamyl-L-arginyl-L-alanyl-L-?-glutamyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-phenylalanyl-L-?-aspartyl-L-seryl-L-valinamide, trifluoroacetate salt
• Correlated keywords
  • 176591-49-4 nondeprived CRF-1 2? 2? CRFBP low density lipoprotein
• Product Overview:
  Urocortin is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF (Item No. 24407), urocortin II (Item Nos. 24746 | 24747), urocortin III (Item Nos. 24748 | 24749 | 24750), frog sauvagine, and piscine urotensin I.{41569} Human urocortin shares 95% sequence homology with rat urocortin (Item No. 24745). Urocortin binds to type 1 and 2 CRF receptors as well as CRF binding protein (CRF-BP) with Ki values of 0.41, 1.8, 1.5, and 0.22 nM for human CRF1, rat CRF2?, mouse CRF2?, and human CRF-BP, respectively. It induces cAMP production in CHO cells expressing human CRF1, rat CRF2?, and mouse CRF2? receptors (EC50s = 0.22, 0.32, and 0.13 nM, respectively). Urocortin induces secretion of adrenocorticotropic hormone (ACTH) by rat anterior pituitary cells in a concentration-dependent manner, an effect that can be inhibited by human CRF-BP. It inhibits migration and proliferation of human vascular smooth muscle cells (VSMCs) and reduces LDL-induced foam cell formation in vitro.{41570} In vivo, urocortin slows development of aortic atherosclerotic lesions in Apoe-/- mice. Urocortin also decreases food intake in food-deprived and non-deprived rats as well as water intake in water-deprived rats in a dose-dependent manner.{41571}