Nrf2 (C-Term) Polyclonal Antibody
Nrf2 (C-Term) Polyclonal Antibody
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor encoded by NFE2L2 in humans that...
€474.00
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From €55.00 €46.75
From €55.00 €46.75
Dapansutrile is a ?-sulfonyl nitrile inhibitor of the NLRP3 inflammasome that inhibits the release of IL-1? and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, human monocyte derived macrophages (HMDMs), and primary human blood neutrophils without affecting TNF-? release.{40704} It is selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 ?M. Dapansutrile inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A.1 cells. In vivo, Dapansutrile reduces myeloperoxidase (MPO), CXCL1, and IL-6 levels in peritoneal fluid as well as IL-1? levels in liver, lung, spleen, and skeletal muscle in a mouse model of LPS-induced systemic inflammation. It decreases oxidized glutathione and oxaloacetate and increases reduced glutathione, ?-ketoglutarate, and citrate levels, markers of oxidative metabolism, in muscle in a mouse model of LPS-induced systemic inflammation. Dapansutrile also reduces IL-1? release in blood monocytes isolated from patients with cryopyrin-associated periodic syndrome (CAPS), an autoinflammatory disorder characterized by gain-of-function mutations in NLRP3.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 100 mg, 250 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 54863-37-5 |
| Molecular formula | C4H7NO2S |
| Smiles | CS(CCC#N)(=O)=O |
| Molecular weight | 133,2 |
| Custom code | 2930.90 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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