Prion Protein (106-126) (trifluoro<wbr/>acetate salt)

Prion Protein (106-126) (trifluoroacetate salt)

CAT N°: 24556
Price:

From 268.00 227.80

Prion Protein (106-126) is a peptide fragment of the cellular prion protein PrPc.{41468} It forms fibrils that are organized into ?-strands, a behavior characteristic of amyloids. It is toxic to primary rat hippocampal neurons at a concentration of 80 ?M following incubation for 10 days and induces DNA fragmentation and apoptosis. Prion Protein (106-126) (25 ?M) activates ERK1 and 2, p38, and JNK1 and 2 kinases, induces apoptosis, increases NADPH oxidase-dependent production of reactive oxygen species (ROS), and decreases glutathione (GSH) levels in 1C115-HT serotonergic and 1C11NE noradrenergic differentiated neuronal cells.{41469} It forms channels in lipid bilayer membranes that are freely permeable to calcium, sodium, potassium, lithium, rubidium, cesium, and chloride ions at a concentration of 20 ?M, and channel formation is significantly enhanced by aging and low pH.{41470} In vivo, intraocular injection of prion protein (106-126) (1 mM) increases the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) positive nuclei in mice 4 days post injection.{41471}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • L-lysyl-L-threonyl-L-asparaginyl-L-methionyl-L-lysyl-L-histidyl-L-methionyl-L-alanylglycyl-L-alanyl-L-alanyl-L-alanyl-L-alanylglycyl-L-alanyl-L-valyl-L-valylglycylglycyl-L-leucyl-glycine, trifluoroacetate salt
  • Correlated keywords
    • 148439-49-0 256481-26-2 ERK JNK 1 2 PrP106-126 fragment
  • Product Overview:
    Prion Protein (106-126) is a peptide fragment of the cellular prion protein PrPc.{41468} It forms fibrils that are organized into ?-strands, a behavior characteristic of amyloids. It is toxic to primary rat hippocampal neurons at a concentration of 80 ?M following incubation for 10 days and induces DNA fragmentation and apoptosis. Prion Protein (106-126) (25 ?M) activates ERK1 and 2, p38, and JNK1 and 2 kinases, induces apoptosis, increases NADPH oxidase-dependent production of reactive oxygen species (ROS), and decreases glutathione (GSH) levels in 1C115-HT serotonergic and 1C11NE noradrenergic differentiated neuronal cells.{41469} It forms channels in lipid bilayer membranes that are freely permeable to calcium, sodium, potassium, lithium, rubidium, cesium, and chloride ions at a concentration of 20 ?M, and channel formation is significantly enhanced by aging and low pH.{41470} In vivo, intraocular injection of prion protein (106-126) (1 mM) increases the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) positive nuclei in mice 4 days post injection.{41471}

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