Xamoterol (hemi<wbr/>fumarate)

Xamoterol (hemifumarate)

CAT N°: 24267
Price:

From 48.00 40.80

Xamoterol is a partial agonist of ?1-adrenergic receptors (?1-ARs) with an EC50 value of 80 nM for the generation of cyclic AMP (cAMP) in neonatal rat cardiomyocyte cultures.{41648} It increases spontaneous contraction of isolated rat right atria (EC50 = 4.67 nM).{41649} In vivo, xamoterol increases heart rate in beagle dogs (ED50 = 3.2 µg/kg) and in a rat model of spontaneous heart failure (ED50 = 6 µg/kg), an effect that is reversed by the selective ?1-AR antagonist betaxolol (Item No. 18625) but not the selective ?2-AR antagonist ICI 118551 (Item No. 15591).{41648,41647} Formulations containing xamoterol have been used in the treatment of heart failure.

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