FSL-1 (trifluoro<wbr/>acetate salt)

FSL-1 (trifluoroacetate salt)

CAT N°: 24220
Price:

From 146.00 124.10

FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6).{36662,36665} In HEK293 cells transfected with human TLR2 and TLR6 but not TLR6 alone, FSL-1 increases NF-?B activity by 4- and 8-fold when used at concentrations of 0.1 and 1 nM, respectively.{36662} It induces the expression of the cytokines CCL20, IL-8, IL-1?, and TNF-? in human monocytic THP-1 cells and, to a lesser extent, in TLR10 knockdown cells when used at a concentration of 100 ng/ml.{36666} FSL-1 (0.5-50 ?g/ml), in combination with IFN-?, dose-dependently increases the percentage of DM13 and VMM1 melanoma cells expressing the chemokine CXCL10 with a maximal increase of approximately 50%.{36663} In rats, FSL-1 (100 ?g/kg, i.p.) induces fever and increases plasma levels of IL-6 and TNF-? by greater than 90-fold.{36664} FSL-1 (10-1,000 ?g/kg, i.p.) also dose-dependently reduces home cage locomotor activity and both food and water consumption with maximal reductions of ten grams per 12 hours.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-?-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine, trifluoroacetate salt
  • Correlated keywords
    • FSL1 TLR-2 6 10 HEK-293 NF?B CCL-20 IL8 IL1? TNF? DM-13 VMM-1 CXCL-10 IL6 IFN? THP1 322455-70-9
  • Product Overview:
    FSL-1 is a synthetic lipopeptide agonist of toll-like receptor 2 (TLR2) and TLR6 heterodimers (TLR2/TLR6).{36662,36665} In HEK293 cells transfected with human TLR2 and TLR6 but not TLR6 alone, FSL-1 increases NF-?B activity by 4- and 8-fold when used at concentrations of 0.1 and 1 nM, respectively.{36662} It induces the expression of the cytokines CCL20, IL-8, IL-1?, and TNF-? in human monocytic THP-1 cells and, to a lesser extent, in TLR10 knockdown cells when used at a concentration of 100 ng/ml.{36666} FSL-1 (0.5-50 ?g/ml), in combination with IFN-?, dose-dependently increases the percentage of DM13 and VMM1 melanoma cells expressing the chemokine CXCL10 with a maximal increase of approximately 50%.{36663} In rats, FSL-1 (100 ?g/kg, i.p.) induces fever and increases plasma levels of IL-6 and TNF-? by greater than 90-fold.{36664} FSL-1 (10-1,000 ?g/kg, i.p.) also dose-dependently reduces home cage locomotor activity and both food and water consumption with maximal reductions of ten grams per 12 hours.

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