24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin).{41427} It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R.{41427} In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling.{41426} Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.{41425}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 168482-23-3 |
| Molecular formula | C54H71N15O9 • XCF3COOH |
| Smiles | O=C([C@@H](NC([C@H](CCCC)NC(C)=O)=O)C1)N[C@@H](CC2=CN=CN2)C(N[C@H](CC3=CC=C(C=CC=C4)C4=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@H](C(N)=O)CCCCNC1=O)=O)=O)=O)=O.FC(F)(C(O)=O)F |
| Molecular weight | 1074,2 |
| Custom code | 2933.29 |
| Formulation | A lyophilized powder |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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