Bombesin (trifluoroacetate salt)

Bombesin (trifluoroacetate salt)

CAT N°: 24151
Price:

49.00 41.65

Bombesin is a neuropeptide with diverse biological activities originally isolated from the skin of B. bombina and B. variegata variegata amphibians.{40598,40599} It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells (Ki = 1.88 nM) and to frog bombesin receptor subtype 4 (BB4) in CHO cells overexpressing the receptor (Ki = 1.7 nM).{40600} Hypothalamic paraventricular microinfusion of bombesin (100 ng per animal) increases blood glucose, free fatty acids, and corticosterone levels in rats.{40601} Bombesin (50 ng per animal) injection into the preoptic area decreases food intake by food-deprived or insulin pretreated rats.{40602} It delays gastric emptying in rats by 55.8% when administered at a dose of 16 ?g/kg (i.p.) and inhibits gastric secretion at a dose of 500 ng per animal.{40603,40604}

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