Substance P (trifluoro<wbr/>acetate salt)

Substance P (trifluoroacetate salt)

CAT N°: 24035
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From 66.00 56.10

Substance P is tachykinin neuropeptide that selectively binds to neurokinin 1 (NK1) receptors (Kis = 0.14 and 300 nM for NK1 and NK3, respectively) and has diverse biological activities.{40688,40689} It is an endogenous peptide expressed in the central and peripheral nervous systems, including the enteric nervous system and in immune cells.{40689} Substance P is released with other neurotransmitters in the dorsal horn of the spinal cord following noxious peripheral stimulation and induces pain through NK1 receptors.{40690} The NK1 receptor is internalized following substance P binding, and in a rat hindpaw model of inflammation it is internalized in a greater number of spinal cord neurons following a mechanical or non-noxious stimuli, indicating a role for substance P in inflammation and hyperalgesia.{40691} Substance P is also involved in depression, anxiety, seizures, and emesis among other functions.{40689}

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