Echothiophate (iodide)

Echothiophate (iodide)

CAT N°: 24029
Price:

From 48.00 40.80

Echothiophate is an organophosphate and acetylcholinesterase (AChE) inhibitor.{37301} It is more active at ocular acetylcholinesterases than those isolated from rabbit brain, liver, or blood. In vivo, topical ocular administration of echothiophate (0.125 and 0.25% w/v) reduces intraocular pressure and induces miosis in dogs with normotensive eyes and those with inherited glaucoma.{37302} It also induces formation of subcapsular cataracts in cynomolgus monkeys.{37303} Formulations containing echothiophate have been used for the treatment of glaucoma.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[(diethoxyphosphinyl)thio]-N,N,N-trimethyl-ethanaminium, monoiodide
  • Correlated keywords
    • 6736-03-4 217-MI ecothiopate ecostigmine ecostigmini jodidum 217MI Diethoxyphosphinylthiocholine Diethylphosphorylthiocholine phospholine
  • Product Overview:
    Echothiophate is an organophosphate and acetylcholinesterase (AChE) inhibitor.{37301} It is more active at ocular acetylcholinesterases than those isolated from rabbit brain, liver, or blood. In vivo, topical ocular administration of echothiophate (0.125 and 0.25% w/v) reduces intraocular pressure and induces miosis in dogs with normotensive eyes and those with inherited glaucoma.{37302} It also induces formation of subcapsular cataracts in cynomolgus monkeys.{37303} Formulations containing echothiophate have been used for the treatment of glaucoma.

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