24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Emedastine is a histamine H1 receptor antagonist (Ki = 1.3 nM).{38529} It is selective for histamine H1 over H2 and H3 receptors (Kis = 49 and 12.43 µM, respectively), as well as ?1-, ?2-, and ?1-adrenergic and dopamine D1 and D2 receptors, and the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 at 10 µM.{38529,38530} Emedastine inhibits histamine-induced phosphoinositide turnover and intracellular calcium mobilization in primary human conjunctival epithelial cells (HCECs; IC50s = 1.6 and 2.9 nM, respectively).{38531} It also inhibits histamine-stimulated secretion of IL-6, IL-8, and GM-CSF by primary HCECs (IC50s = 2.23, 3.42, and 1.50 nM, respectively).{38532} Ocular application of emedastine prior to histamine challenge inhibits vascular permeability in guinea pigs.{38530} Formulations containing emedastine have been used in the treatment of allergic conjunctivitis.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 87233-62-3 |
| Molecular formula | C17H26N4O • 2C4H4O4 |
| Smiles | CN(CC1)CCCN1C2=NC3=CC=CC=C3N2CCOCC.OC(/C=C/C(O)=O)=O.OC(/C=CC(O)=O)=O, CN(CC1)CCCN1C2=NC3=CC=CC=C3N2CCOCC.OC(/C=C/C(O)=O)=O.OC(/C=CC(O)=O)=O, CN(CC1)CCCN1C2=NC3=CC=CC=C3N2CCOCC.OC(/C=C/C(O)=O)=O.OC(/C=CC(O)=O)=O, CN(CC1)CCCN1C2=NC3=CC=CC=C3N2CCOCC.OC(/C=C/C(O)=O)=O.OC(/C=CC(O)=O)=O |
| Molecular weight | 534,6 |
| Custom code | 2921.30 |
| Formulation | A solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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