Dicyclomine (hydro<wbr/>chloride)

Dicyclomine (hydrochloride)

CAT N°: 23867
Price:

29.00 24.65

Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively).{41413} It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol; Item No. 14486) in guinea pig cortex (Ki = 12 nM; pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively.{41414} Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.

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