Avobenzone

Avobenzone

CAT N°: 23836
Price:

From 92.00 78.20

Avobenzone is a full-spectrum ultraviolet A (UVA) blocker.{41451} It inhibits UVA-induced increases in melanin levels and tyrosinase activity in B16/F10 melanoma cells (IC30s = 21.94 and 24.25 ?M, respectively).{41452} Avobenzone (30 ?M) also inhibits UVA-induced production of reactive oxygen species (ROS) and 8-hydroxy-2′-deoxyguanosine (8-OH-dG; Item No. 89320), as well as inhibits UVA-induced depletion of glutathione (GSH; Item No. 10007461), in B16/F10 cells. It increases nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the antioxidant response element (ARE) in UVA-irradiated B16/F10 cells when used at at a concentration of 30 ?M. Formulations containing avobenzone have been used as a sun protectant in sunscreen products.

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