PD 166793

PD 166793

CAT N°: 23762
Price:

From 182.00 154.70

PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 ?M for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively).{39768} It reverses peroxynitrite-induced decreases in contraction cease time, a measure of cardiac contractility, in isolated rat ventricular myocytes when used at a concentration of 2 ?M.{39769} In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure.{39770} It reduces LV dilation and preserves systolic function in a rat model of progressive heart failure.{39768} PD 166793 also inhibits age-associated increases in aortic gelatinase and interstitial collagenase activity and mean arterial pressure in rats.{39771}

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