Tedizolid Phosphate

Tedizolid Phosphate

CAT N°: 23729
Price:

48.00 40.80

Tedizolid phosphate is a prodrug form of tedizolid, an antibiotic with activity against Gram-positive bacteria.{40653} Tedizolid phosphate is rapidly converted by non-specific phosphatases to tedizolid, which inhibits the growth of S. aureus, S. epidermidis, E. faecalis, E. faecium, S. pneumoniae, and S. pyogenes (MICs = 0.25-1 ?g/ml). In vivo, tedizolid phosphate (15 mg/kg) reduces vegetation titer in a rabbit model of aortic valve endocarditis caused by methicillin-resistant S. aureus (MRSA).{40654} It also reduces densities of methicillin-susceptible S. aureus and MRSA infection in a mouse model of catheter-related biofilm infection and increases survival in a rabbit model of MRSA necrotizing pneumonia.{40655,40656}

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