6-<wbr/>Aminocaproic Acid

6-Aminocaproic Acid

CAT N°: 23724
Price:

85.00 72.25

6-Aminocaproic acid is an inhibitor of the plasmin activating enzymes streptokinase, fibrinokinase, and urokinase (IC50s = ~8 ?M for all in an enzyme assay).{37233} It is selective for plasmin activating enzymes over trypsin (IC50 = >500 ?M). 6-Aminocaproic acid inhibits in vitro plasmin activation and fibrinolysis in a dose-dependent manner. Ex vivo, 6-aminocaproic acid reduces fibrinolysis in dog plasma following i.p. administration at doses ranging from 20-100 mg/kg.{37234} Formulations containing 6-aminocaproic acid have been used to decrease postoperative blood transfusion rates following knee surgery.{37235}

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