Besifloxacin (hydro<wbr/>chloride)

Besifloxacin (hydrochloride)

CAT N°: 23692
Price:

From 66.00 56.10

Besifloxacin is an ophthalmologic fluoroquinolone antibiotic that is active against Gram-negative and Gram-positive aerobic and anaerobic bacterial strains (MICs = 0.006-1.56 ?g/ml).{38427} It inhibits LPS-stimulated production of the inflammatory cytokines IL-1?, IL-8, IL-6, and IL-1? in human THP-1 monocytes.{38428} Besifloxacin, when 2 drops of a 0.6% solution are applied per eye, yields a concentration of 2 ?g/g which is greater than the MIC90s of ophthalmologic isolates of H. influenzae, S. pneumoniae, S. aureus, and Corynebacterium and reduces the number of bacteria found in the aqueous, but not vitreous, humor in a rabbit model of bacterial endophthalmitis.{38427,38429}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride
  • Correlated keywords
    • 141388-76-3 SS734 SS-734 BOL303224A BOL303224 303224A Besivance IL1? IL8 IL6 IL1? THP1 Haemophilus Streptococcus Staphylococcus anti-biotic lipopolysaccharide IL1B IL1a
  • Product Overview:
    Besifloxacin is an ophthalmologic fluoroquinolone antibiotic that is active against Gram-negative and Gram-positive aerobic and anaerobic bacterial strains (MICs = 0.006-1.56 ?g/ml).{38427} It inhibits LPS-stimulated production of the inflammatory cytokines IL-1?, IL-8, IL-6, and IL-1? in human THP-1 monocytes.{38428} Besifloxacin, when 2 drops of a 0.6% solution are applied per eye, yields a concentration of 2 ?g/g which is greater than the MIC90s of ophthalmologic isolates of H. influenzae, S. pneumoniae, S. aureus, and Corynebacterium and reduces the number of bacteria found in the aqueous, but not vitreous, humor in a rabbit model of bacterial endophthalmitis.{38427,38429}

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