Mefloquine (hydro<wbr/>chloride)

Mefloquine (hydrochloride)

CAT N°: 23665
Price:

From 74.00 62.90

Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • rel-?S-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol, monohydrochloride
  • Correlated keywords
    • 53230-10-7 68682-28-0 Mefloquin Loriam NSC157387 Ro21 Ro215998/001 ro215998001 WR142490 anti-malarial depressant A-2A 5HT2A 5HT2C WR 142490 Confal Facital Lariam Larimef Mefax Mefcy Mefliam Mefloc Meflotas Mepalex Mephaquin Mqf 51742-86-0
  • Product Overview:
    Mefloquine is an orally bioavailable quinolinemethanol derivative with antimalarial properties.{38380} It increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively. It inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites.{38381} It acts as an antagonist at the adenosine A2A receptor, an agonist at serotonin 5-HT2A and 5-HT2C receptors, and has various effects on calcium homeostasis.{38382,38383} Mefloquine increases the time mice spend in the light side of the light-dark box test and reduces immobility time in the tail suspension test, parameters typically associated with anxiolytic and antidepressant-like behavior.{38383} Formulations containing mefloquine have been used to prevent and treat malaria but have been associated with neuropsychiatric disturbances.

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