Cholera Toxin (azide free)

CAT N°: 19654
Price:

439.00 373.15

Cholera toxin is produced by V. cholerae and is a multimeric enterotoxin that consists of a single A subunit surrounded by five B subunits.{31319} Following binding to the membrane of enteric cells, the toxin is endocytosed and travels to the endoplasmic reticulum where the enzymatically active A subunit (CTA1) is translocated to the cytosol. Within the cytosol, CTA1 catalyzes the ADP-ribosylation of the Gs? protein, which activates adenylate cyclase, locking it in an ‘on’ position.{31320} The increased intracellular concentration of cAMP causes hypersecretion of chloride and bicarbonate ions, which results in increased fluid secretion and severe diarrhea characteristic of the disease cholera.{31319}

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