FQI 1

FQI 1

CAT N°: 23104
Price:

From 163.00 138.55

FQI 1 is an inhibitor of Late SV40 Factor (LSF) transactivation activity (IC50 = 2.1 µM).{49248} It inhibits growth of NIH3T3, HeLa S3, and A549 cancer cells (GI50s = 3.8, 0.79, and 6.3 µM, respectively). FQI 1 decreases viability of QGY-7703 and Huh7 liver cancer cells, but not of non-cancerous Hc3716-hTERT cells and primary mouse hepatocytes, when used at a concentration of 4 µM.{49248,49249} It reduces tumor growth induced by N-nitrosodiethylamine (DEN) in mice and in a QGY-7703 hepatocellular carcinoma (HCC) mouse xenograft model when administered at doses of 4 and 1 mg/kg, respectively.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 8-(2-ethoxyphenyl)-7,8-dihydro-1,3-dioxolo[4,5-g]quinolin-6(5H)-one
  • Correlated keywords
    • FQI1 SV-40 NIH3-T3 T S 3 A-549 QGY7703 Huh-7 noncancerous Hc-3716 Hc3716hTERT
  • Product Overview:
    FQI 1 is an inhibitor of Late SV40 Factor (LSF) transactivation activity (IC50 = 2.1 µM).{49248} It inhibits growth of NIH3T3, HeLa S3, and A549 cancer cells (GI50s = 3.8, 0.79, and 6.3 µM, respectively). FQI 1 decreases viability of QGY-7703 and Huh7 liver cancer cells, but not of non-cancerous Hc3716-hTERT cells and primary mouse hepatocytes, when used at a concentration of 4 µM.{49248,49249} It reduces tumor growth induced by N-nitrosodiethylamine (DEN) in mice and in a QGY-7703 hepatocellular carcinoma (HCC) mouse xenograft model when administered at doses of 4 and 1 mg/kg, respectively.

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