Valrubicin

Valrubicin

CAT N°: 22964
Price:

From 128.00 108.80

Valrubicin is a semisynthetic anthracycline antitumor antibiotic and derivative of doxorubicin (Item No. 15007).{40337} It inhibits the growth of human bladder tumor cell lines with LD50 values ranging from 0.05 to 11.2 ?M.{40339} Valrubicin is more active against cells in the plateau growth phase than in the log growth phase (LD70s = 2.5 and 12.1 ?M, respectively for CUB-2 cells). Valrubicin (40 mg/kg) increases survival in mice with murine P388 and L1210 leukemias.{40337} Topical administration of valrubicin (0.01 g/ml) reduces epidermal thickness and normalizes epidermal morphology in a mouse psoriasis xenograft transplantation model.{40338} Formulations containing valrubicin have been used in the treatment of bladder cancer.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • pentanoic acid, 2-[(2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-?-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl ester
  • Correlated keywords
    • 136816-53-0 AD 32 AD32 Trifluoroacetyldoxorubicin NSC246131 Valstar Trifluoro acetyl doxorubicin CUB2 P 388 L 1210 smei-synthetic anti-tumor biotic
  • Product Overview:
    Valrubicin is a semisynthetic anthracycline antitumor antibiotic and derivative of doxorubicin (Item No. 15007).{40337} It inhibits the growth of human bladder tumor cell lines with LD50 values ranging from 0.05 to 11.2 ?M.{40339} Valrubicin is more active against cells in the plateau growth phase than in the log growth phase (LD70s = 2.5 and 12.1 ?M, respectively for CUB-2 cells). Valrubicin (40 mg/kg) increases survival in mice with murine P388 and L1210 leukemias.{40337} Topical administration of valrubicin (0.01 g/ml) reduces epidermal thickness and normalizes epidermal morphology in a mouse psoriasis xenograft transplantation model.{40338} Formulations containing valrubicin have been used in the treatment of bladder cancer.

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