Ametantrone

Ametantrone

CAT N°: 22924
Price:

From 66.00 56.10

Ametantrone is an inhibitor of topoisomerase II.{46347} It induces double-strand breaks in SV40 DNA in the presence, but not absence, of topoisomerase II and induces single-strand breaks in DNA in NCI H187 cells.{46347,46348} It also induces interstrand DNA cross-links in HeLa S3 cells at a minimum concentration of 4.1 µM.{46349} Ametantrone is cytotoxic to NCI H187 and HL-60 cells (IC50s = 112 and 0.44 µM, respectively). It inhibits tumor growth in a Ridgway osteogenic sarcoma mouse model when administered at a dose of 5 mg/kg, however, it increases tumor growth in mouse models of mammary adenocarcinoma and colon adenocarcinoma 11a.{46350}

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