APY-29

APY-29

CAT N°: 22913
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From 156.00 132.60

APY-29 is a modulator of inositol requiring enzyme 1 ? (IRE1?), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{36117} It binds to the ATP-binding site on IRE1?, where it inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM). In vitro, it restores the ability of dephosphoylated IRE1? to cleave XBP1 mRNA in a dose-dependent manner. It also enhances IRE1? oligomerization in a crosslinking assay.

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