Rutaecarpine

Rutaecarpine

CAT N°: 22897
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74.00 62.90

Rutaecarpine is a quinazolinone alkaloid originally isolated from E. rutaecarpa that has diverse biological activities.{36146} It inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM, respectively) and is selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 µM, for COX-1 and COX-2, respectively).{36144} It slows the growth of cancer cells in vitro with GI50 values of 8.41-31.6 µM.{36146} It also has cardiovascular properties, inducing dose-dependent vasodilation (0.1-10 µM) of precontracted isolated rat aorta and inhibiting platelet aggregation.{36143} In addition, rutaecarpine (80 mg/kg) decreases plasma levels of caffeine in rat by inducing its metabolism through the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2E1.{36145}

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