BMS 582949

BMS 582949

CAT N°: 22892
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From 116.00 98.60

BMS 582949 is an orally bioavailable p38? MAP kinase inhibitor (IC50 = 13 nM in an enzyme assay).{39188} It also inhibits TNF-? production in human peripheral blood mononuclear cells (PBMC; IC50 = 50 nM). When administered at a dose of 5 mg/kg in mice, it decreases LPS-induced TNF-? production up to 89% compared to vehicle. BMS 582949 reduces paw swelling in a rat adjuvant arthritis model when administered once per day (1, 10, or 100 mg/kg) or twice per day (1 or 5 mg/kg).

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TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...

€191.00
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