BMS 582949

BMS 582949

CAT N°: 22892
Price:

From 116.00 98.60

BMS 582949 is an orally bioavailable p38? MAP kinase inhibitor (IC50 = 13 nM in an enzyme assay).{39188} It also inhibits TNF-? production in human peripheral blood mononuclear cells (PBMC; IC50 = 50 nM). When administered at a dose of 5 mg/kg in mice, it decreases LPS-induced TNF-? production up to 89% compared to vehicle. BMS 582949 reduces paw swelling in a rat adjuvant arthritis model when administered once per day (1, 10, or 100 mg/kg) or twice per day (1 or 5 mg/kg).

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
  • Correlated keywords
    • 1023292-44-5 BMS52949 MAPK TNF?
  • Product Overview:
    BMS 582949 is an orally bioavailable p38? MAP kinase inhibitor (IC50 = 13 nM in an enzyme assay).{39188} It also inhibits TNF-? production in human peripheral blood mononuclear cells (PBMC; IC50 = 50 nM). When administered at a dose of 5 mg/kg in mice, it decreases LPS-induced TNF-? production up to 89% compared to vehicle. BMS 582949 reduces paw swelling in a rat adjuvant arthritis model when administered once per day (1, 10, or 100 mg/kg) or twice per day (1 or 5 mg/kg).

We also advise you