2'-C-Methyl<wbr/>cytidine

2′-C-Methylcytidine

CAT N°: 22887
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From 129.00 109.65

2′-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity.{37119} It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 ?M, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 ?M in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 ?M) and human coronavirus (HCoV; EC50 = 90 ?M). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 ?M) and swine vesicular disease virus (SVDV; EC50 = 45.2 ?M).{37120} In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.{37121}

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