2',3'-Dideoxy<wbr/>adenosine 5'-triphosphate (lithium salt)

2′,3′-Dideoxyadenosine 5′-triphosphate (lithium salt)

CAT N°: 17460
Price:

196.00 166.60

2′,3′-Dideoxyadenosine 5′-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively).{28262,28268,28264} It also blocks, in vitro, mammalian and bacterial DNA polymerases.{28265,28263} ddATP, produced intracellularly by the phosphorylation of exogenously supplied 2’,3’-dideoxyadenosine, competes with dATP, resulting in chain termination.{28265,28263} Because of this activity, dideoxynucleoside 5’-triphosphates, including ddATP, are used to terminate chain extension produced by the Taq polymerase used in polymerase chain reactions.{28266} It is also an antagonist of the purinergic receptor P2X2/3 (pIC50 = 6.5).{28267}

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