Brazilin

Brazilin

CAT N°: 22456
Price:

From 48.00 40.80

Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.{41009} Brazilin inhibits A? (1-42) fibrillogenesis (IC50 = 1.5 µM) more potently than (-)-epigallocatechin gallate (Item No. 70935), cucurmin (Item No. 81025), and resveratrol (Item Nos. 10004235 | 70675).{41007} It also prevents remodeling of mature A? (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 (Item No. 14010) and TNF-? (IC50s = 12.6 and 87.2 µM).{41011} It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 µg/ml.{41010} In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.{41008}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 7,11bR-dihydro-benz[b]indeno[1,2-d]pyran-3,6aS,9,10(6H)-tetrol
  • Correlated keywords
    • 22562-62-5 brazilwood Braziletto NSC56652 Superbresiline Limawood Extract Receptor antiinflammatory anti-bacterial oxidant brasilin
  • Product Overview:
    Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.{41009} Brazilin inhibits A? (1-42) fibrillogenesis (IC50 = 1.5 µM) more potently than (-)-epigallocatechin gallate (Item No. 70935), cucurmin (Item No. 81025), and resveratrol (Item Nos. 10004235 | 70675).{41007} It also prevents remodeling of mature A? (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 (Item No. 14010) and TNF-? (IC50s = 12.6 and 87.2 µM).{41011} It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 µg/ml.{41010} In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.{41008}

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