Falcarinol

Falcarinol

CAT N°: 22407
Price:

From 102.00 86.70

Falcarinol is a C17-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis.{38102,38105} Falcarinol binds to the human recombinant cannabinoid (CB) receptors, CB1 and CB2, (Kis = 594 and 2,100 nM, respectively) in an [3H]anandamide displacement assay in HEK293 cells.{38104} It differentially modulates synaptic and extrasynaptic GABAA receptors in a recombinant HEK293 system.{38101} In vitro assays of ATPase activity demonstrate that falcarinol inhibits breast cancer resistance protein ATP-binding cassette sub-family G member 2 (ABCG2; IC50 = 79.3 ?M), a drug efflux transporter and mediator of drug resistance.{38106} Falcarinol (6.88 ?g/g feed) also inhibits aberrant crypt foci by 26.6% in azoxymethane-induced rats.{38103}

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