FFAR2 (GPR43) (Internal) Polyclonal Antibody

FFAR2 (GPR43) (Internal) Polyclonal Antibody

CAT N°: 15727
Price:

474.00 402.90

GPR43 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).{25541,25605,25606} Several SCFAs have the potential to bind and activate GPR43, including acetate, formate, propionate, and butyrate.{25605} GPR43 couples through the Pertussis toxin-sensitive Gi/o and the pertussis toxin-insensitive Gq protein families and its expression has been described in enteroendocrine cells and neutrophils.{25606,25605} The activation of GPR43 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP.{25606,25605,25541} Activation of GPR43 may be involved in intestinal inflammation. The predicted size of GPR43 is 37 kDa. Cayman’s GPR43 (Internal) Polyclonal Antibody detects a 37 kDa band in cell lysates.

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • GPR43 short chains fatty acids neutrophils enteroendocrine GPRs GPR-43 43 g proteins coupled receptors SCFAs acetate formate propionate butyrate intestinal inflammation cells lysates ELISA western blots WB blotting signals transduction lipids mediators intracellular signaling immunofluorescence IF flows cytometry FCs binding binds binders proteins antibodies GPCRs anti-FFAR2 FFAR2 protein-coupled Ca2+ calcium ERK1/2 activation cAMP cyclic AMP binding
  • Product Overview:
    GPR43 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).{25541,25605,25606} Several SCFAs have the potential to bind and activate GPR43, including acetate, formate, propionate, and butyrate.{25605} GPR43 couples through the Pertussis toxin-sensitive Gi/o and the pertussis toxin-insensitive Gq protein families and its expression has been described in enteroendocrine cells and neutrophils.{25606,25605} The activation of GPR43 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP.{25606,25605,25541} Activation of GPR43 may be involved in intestinal inflammation. The predicted size of GPR43 is 37 kDa. Cayman’s GPR43 (Internal) Polyclonal Antibody detects a 37 kDa band in cell lysates.

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