Ipsapirone

Ipsapirone

CAT N°: 22075
Price:

From 122.00 103.70

Ipsapirone is a partial agonist of the serotonin (5-HT) receptor 5-HT1A (Ki = 10 nM in hippocampal membranes).{35118} It reduces 5-HT release in rat ventral hippocampus in vivo.{35119} Low doses of ipsapirone decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens.{35120} Extracellular dopamine levels in murine striatum increase following administration of ipsapirone at concentrations >0.1 mg/kg. Ipsapirone has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively).{35121} Formulations containing ipsapirone have been used to treat depression and borderline personality disorder.{35122}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one, 1,1-dioxide
  • Correlated keywords
    • 5HT 5-HT1A 5HT1A 5-HT-1A 5HT-1A SR-1A TVXQ7821 TVX-Q-7821 TVXQ-7821 BPD
  • Product Overview:
    Ipsapirone is a partial agonist of the serotonin (5-HT) receptor 5-HT1A (Ki = 10 nM in hippocampal membranes).{35118} It reduces 5-HT release in rat ventral hippocampus in vivo.{35119} Low doses of ipsapirone decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens.{35120} Extracellular dopamine levels in murine striatum increase following administration of ipsapirone at concentrations >0.1 mg/kg. Ipsapirone has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively).{35121} Formulations containing ipsapirone have been used to treat depression and borderline personality disorder.{35122}

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