MONNA

MONNA

CAT N°: 21917
Price:

From 48.00 40.80

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 µM in Xenopus oocytes), a calcium-activated chloride channel (CaCC).{34636} It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 µM. MONNA (10 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.{34635} It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
  • Correlated keywords
    • TMEM16A ANO-1 Ca CC
  • Product Overview:
    MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 µM in Xenopus oocytes), a calcium-activated chloride channel (CaCC).{34636} It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 µM. MONNA (10 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.{34635} It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

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