Propafenone (hydro<wbr/>chloride)

Propafenone (hydrochloride)

CAT N°: 21871
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48.00 40.80

Propafenone is a class I antiarrhythmic agent.{34127} It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively).{34127,34126} Propafenone also blocks sodium (INa), potassium (IK), and transient outward potassium currents in various cardiac cells.{34126,34128,34130} In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia.{57430} Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.

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