Bithionol

Bithionol

CAT N°: 21844

Bithionol is an anthelmintic drug. Formulations containing bithionol have demonstrated efficacy against cestodes and trematodes, as well as other parasitic worms.{34401,34402,34403} Bithionol inhibits host caspases, including caspases-1, -3, -6, -7, and -9, which act as hub proteins that mediate the lethality of multiple pathogenic agents.{34404} By blocking host caspases, bithionol reduces the detrimental effects of anthrax lethal toxin, diphtheria toxin, cholera toxin, P. aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus.{34404} Bithionol also inhibits NF-?B activation by blocking phosphorylation of I?B? (IC50 = 15.8 µM in a reporter gene assay).{31081}

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Dangerous Good in said quantity, not available for sale.

  • Synonyms
    • 2,2′-thiobis[4,6-dichloro-phenol]
  • Correlated keywords
    • actamer bidiphen bisoxyphen bithin bitin bitionol CP3438 D26 D-26 lorothidol lorothiodol NSC47129 NSC9872 neopellis nobacter TKhSD vancide BL vancidebl XL7 XL-7 pseudomonas nfkb ikba
  • Product Overview:
    Bithionol is an anthelmintic drug. Formulations containing bithionol have demonstrated efficacy against cestodes and trematodes, as well as other parasitic worms.{34401,34402,34403} Bithionol inhibits host caspases, including caspases-1, -3, -6, -7, and -9, which act as hub proteins that mediate the lethality of multiple pathogenic agents.{34404} By blocking host caspases, bithionol reduces the detrimental effects of anthrax lethal toxin, diphtheria toxin, cholera toxin, P. aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus.{34404} Bithionol also inhibits NF-?B activation by blocking phosphorylation of I?B? (IC50 = 15.8 µM in a reporter gene assay).{31081}

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