Ganglioside G<sub>M3</sub> Mixture (sodium salt)

Ganglioside GM3 Mixture (sodium salt)

CAT N°: 15587
Price:

384.00 326.40

Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and pro-apoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.{25490,25485} It suppresses angiogenesis and reduces proliferation and migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 20 ?M via inhibition of VEGFR2 and Akt phosphorylation.{25490,25485} Ganglioside GM3 induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance in adipocytes.{25481} Ganglioside GM3 mixture contains ganglioside GM3 molecular species with C18:1 and C20:1 sphingoid backbones.

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