Batefenterol

Batefenterol

CAT N°: 21793
Price:

From 74.00 62.90

Batefenterol is a muscarinic antagonist and ?2-adrenergic receptor (?2-AR) agonist (Kis = 1.4, 1.3, and 3.7 nM, for hM2, hM3, and h?2-AR, respectively in a radioligand binding assay).{40016, 40017} Batefenterol exhibits potent h?2-AR agonist activity (EC50 = 0.29 nM) with 440- and 320-fold functional selectivity over h?1- and h?3-ARs, respectively.{40016} Batefenterol induces smooth muscle relaxation (EC50 = 11 nM) in isolated guinea pig tracheal tissue and inhibits bronchoconstrictor response in a guinea pig bronchoprotection assay (ED50 = 6.4 µg/ml).{40016}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[1,1′-biphenyl]-2-yl-carbamic acid, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester
  • Correlated keywords
    • GSK 961081 TD5959 beta MABA bronchodilator bifunctional lung airway
  • Product Overview:
    Batefenterol is a muscarinic antagonist and ?2-adrenergic receptor (?2-AR) agonist (Kis = 1.4, 1.3, and 3.7 nM, for hM2, hM3, and h?2-AR, respectively in a radioligand binding assay).{40016, 40017} Batefenterol exhibits potent h?2-AR agonist activity (EC50 = 0.29 nM) with 440- and 320-fold functional selectivity over h?1- and h?3-ARs, respectively.{40016} Batefenterol induces smooth muscle relaxation (EC50 = 11 nM) in isolated guinea pig tracheal tissue and inhibits bronchoconstrictor response in a guinea pig bronchoprotection assay (ED50 = 6.4 µg/ml).{40016}

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