Leptomycin A

Leptomycin A

CAT N°: 21762
Price:

From 66.00 56.10

Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins.{15319} Leptomycin A inhibits Rev translocation, though less potently than leptomycin B (Item No. 10004976) with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours.{31689} Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2E,6R)-19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5S,7S,9R,11,15R,17-heptamethyl-8-oxo-2,10E,12E,16Z,18E-nonadecapentaenoic acid
  • Correlated keywords
    • NSC369326 jildamycin clindamycin evoclin clindamax clindagel cleocin crm-1 hiv1 anti-fungal anti-biotic
  • Product Overview:
    Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins.{15319} Leptomycin A inhibits Rev translocation, though less potently than leptomycin B (Item No. 10004976) with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours.{31689} Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.

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