Theobromine

Theobromine

CAT N°: 21745
Price:

From 48.00 40.80

Theobromine is a methylxanthine alkaloid and derivative of caffeine (Item No. 14118) that has been found in cocoa beans and has diverse biological activities.{34451,34450,34453} It is an adenosine A1 receptor antagonist (IC50s = 200-280 ?M in radioligand binding assays using rat brain membranes).{34450} Theobromine (150 ?g/ml) increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-? production in 3T3-L1 preadipocytes cultured in differentiation medium.{34451} It inhibits decreases in renal cortex SIRT1 activity and increases in NADPH oxidase-dependent reactive oxygen species (ROS) production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes when administered at a dose of 5 mg/kg per day.{34453} Theobromine is toxic to dogs with an LD50 value of 250 to 500 mg/kg.{34454}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione
  • Correlated keywords
    • 3,7-dimethylxanthine NSC5039 SC15090 santheose teobromin theobromine theosalvose theostene thesal methyl xanthine radio ligand IL6 TNF? 3T3L1 SIRT-1 hyper trophy tensive
  • Product Overview:
    Theobromine is a methylxanthine alkaloid and derivative of caffeine (Item No. 14118) that has been found in cocoa beans and has diverse biological activities.{34451,34450,34453} It is an adenosine A1 receptor antagonist (IC50s = 200-280 ?M in radioligand binding assays using rat brain membranes).{34450} Theobromine (150 ?g/ml) increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-? production in 3T3-L1 preadipocytes cultured in differentiation medium.{34451} It inhibits decreases in renal cortex SIRT1 activity and increases in NADPH oxidase-dependent reactive oxygen species (ROS) production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes when administered at a dose of 5 mg/kg per day.{34453} Theobromine is toxic to dogs with an LD50 value of 250 to 500 mg/kg.{34454}

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