HMG-<wbr/>CoA Reductase (human recombinant)

HMG-CoA Reductase (human recombinant)

CAT N°: 14944
Price:

460.00 391.00

HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER) membrane. It is bound to the ER membrane by a multi-pass 339 amino acid N-terminal transmembrane domain while the carboxy terminal catalytic region projects into the cytosol.{26861,26862} HMGR is controlled by feedback regulation from sterols and non-sterol metabolites derived from mevalonate.{26862,26863,26860} Binding of cholesterol derived from internalized LDL receptors suppresses HMGR. The enzyme is responsible for catalyzing the rate-limiting step in cholesterol biosynthesis. Mevalonate, which is converted to isopentenyl pyrophosphate, is the building block for cholesterol and non-sterol isoprenoids. The four-electron reduction of HMG-CoA catalyzed by HMGR to form mevalonate is the committed step in the biosynthesis of sterols and isoprenoids.{15309} Potent inhibitors of HMGR, collectively called statins, are effective in lowering mortality due to hypercholesterolemia by lowering serum cholesterol levels.{26864}

Territorial Availability: Available through Bertin Technologies only in France

  • Correlated keywords
    • cholesterol mevalonate hyperlipidemia cardiovasular disease cancers cell biology recombinant proteins HMGR isoprenoids statins P04035 HMG CoA HMGCoA
  • Product Overview:
    HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER) membrane. It is bound to the ER membrane by a multi-pass 339 amino acid N-terminal transmembrane domain while the carboxy terminal catalytic region projects into the cytosol.{26861,26862} HMGR is controlled by feedback regulation from sterols and non-sterol metabolites derived from mevalonate.{26862,26863,26860} Binding of cholesterol derived from internalized LDL receptors suppresses HMGR. The enzyme is responsible for catalyzing the rate-limiting step in cholesterol biosynthesis. Mevalonate, which is converted to isopentenyl pyrophosphate, is the building block for cholesterol and non-sterol isoprenoids. The four-electron reduction of HMG-CoA catalyzed by HMGR to form mevalonate is the committed step in the biosynthesis of sterols and isoprenoids.{15309} Potent inhibitors of HMGR, collectively called statins, are effective in lowering mortality due to hypercholesterolemia by lowering serum cholesterol levels.{26864}

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