BAY 12-17389

BAY 12-17389

CAT N°: 21660
Price:

From 55.00 46.75

BAY 12-17389 is an inhibitor of monopolar spindle 1 (Mps1 or TTK; IC50 = 0.27 nM), a serine/threonine/tyrosine kinase involved in cell division.{34467} It is orally bioavailable and, through its effects on Mps1, inactivates the spindle assembly checkpoint, accelerates mitosis, and causes chromosomal misalignment and missegregation.{34467} BAY 12-17389 induces cell death in Mps1-overexpressing cancer cells and improves efficacy of paclitaxel (Item No. 10461) in tumor therapy.{34467}

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