From €48.00 €40.80
Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. 11017) and has diverse biological activities.{40199,39853,39854,39855} It increases the doubling time and transcription of retinoic acid receptor ? (RAR?) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 ?M.{39853} Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 ?M).{39854} It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 ?M. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-? and IL-10 in allografts in chronic Fisher344?Lewis transplant mice, an allograft nephropathy model.{39855} It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg.{39856} Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 g, 100 mg, 5 g, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 4759-48-2 |
| Molecular formula | C20H28O2 |
| Smiles | CC1=C(/C=C/C(C)=C/C=C/C(C)=CC(O)=O)C(C)(C)CCC1, CC1=C(/C=C/C(C)=C/C=C/C(C)=CC(O)=O)C(C)(C)CCC1, CC1=C(/C=C/C(C)=C/C=C/C(C)=CC(O)=O)C(C)(C)CCC1, CC1=C(/C=C/C(C)=C/C=C/C(C)=CC(O)=O)C(C)(C)CCC1 |
| Molecular weight | 300,4 |
| Custom code | 2902.90 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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