Isotretinoin

Isotretinoin

CAT N°: 21648
Price:

48.00 40.80

Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. 11017) and has diverse biological activities.{40199,39853,39854,39855} It increases the doubling time and transcription of retinoic acid receptor ? (RAR?) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 ?M.{39853} Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 ?M).{39854} It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 ?M. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-? and IL-10 in allografts in chronic Fisher344?Lewis transplant mice, an allograft nephropathy model.{39855} It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg.{39856} Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.

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